Potential Differential Marker in the Diagnosis of Leptospirosis

Human leptospirosis, or commonly known as the “rat urine disease” is a zoonotic disease caused by bacterium called Leptospira sp. acquired via of animal carriers. It believed that incidence rate leptospirosis has been under-reported due to its unspecific clinical Symptoms and limitations current diagnostic methods. Leptospirosis can be effectively treated with antibiotics in early stage, it curable disease. But accuracy diagnose infection rarely achieved. The present study investigated plasma protein profiles lleptospirosis patients who presented different presentations, compared them against two control groups consisting dengue healthy individuals. digests were analyzed using shotgun approach liquid chromatography-tandem mass spectrometry (LC-MS/MS) described manufacturer. proteins detected every patient at least two-fold differential expression statistical significance (p<0.05) identified. Lipopolysaccharide (LPS)-binding (LBP) reported only fulfilled selection criteria. characteristics roles LBP immune system during infections are reviewed. Compared other proteome-based studies on human leptospirosis. first one significant differentially expressed proteins. Potential coupling disease-specific biomarkers diagnosisand prognosis should considered.